Interaction Map and Selection of microRNA Targets in Parkinson's Disease-Related Genes
Joint Authors
Sarma, Pranjal
Bhadra, Utpal
Santosh P., Shinde
Pal-Bhadra, Manika
Arora, Neelima
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Parkinson's disease (PD) is a complex multigenic neurodisorder frequently occurring in elderly persons.
To investigate noncoding tiny microRNA mediated gene regulation, miRanda (version 1.0b) was used to predict human miRNA target sites on selected 29 genes related to PD.
To verify output generated from miRanda, a similar analysis was performed only for microRNA target sites in 3′UTR using TargetScan (version 5.1).
Data extracted by miRanda elucidates the mode of microRNA action based on the location of target sites in the Parkinson genes.
Sites prone to action of multiple miRNAs were identified as “hot spots.” Important properties of each miRNA including multiplicity and cooperativity appear to contribute towards a complex interplay between miRNAs and their targets.
Two sets of predicted results were explored for the occurrence of target sites of 112 miRNAs expressed in midbrain.
Overall, convergence of results predicted by two algorithms revealed that 48 target sites for midbrain-specific miRNA occur in close proximity in 9 genes.
This study will pave a way for selection of potential miRNA candidates for Parkinson's disease-related genes for quick therapeutic applications and diagnosis.
American Psychological Association (APA)
Santosh P., Shinde& Arora, Neelima& Sarma, Pranjal& Pal-Bhadra, Manika& Bhadra, Utpal. 2009. Interaction Map and Selection of microRNA Targets in Parkinson's Disease-Related Genes. BioMed Research International،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988356
Modern Language Association (MLA)
Santosh P., Shinde…[et al.]. Interaction Map and Selection of microRNA Targets in Parkinson's Disease-Related Genes. BioMed Research International No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-988356
American Medical Association (AMA)
Santosh P., Shinde& Arora, Neelima& Sarma, Pranjal& Pal-Bhadra, Manika& Bhadra, Utpal. Interaction Map and Selection of microRNA Targets in Parkinson's Disease-Related Genes. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988356