Clinical Significance of Epigenetic Inactivation of hMLH1 and BRCA1 in Tunisian Patients with Invasive Breast Carcinoma
Joint Authors
Sellami-Boudawara, Tahia
Daoud, Jamel
Frikha, Mounir
Mokdad-Gargouri, Raja
Karray-Chouayekh, Sondes
Trifa, Fatma
Gargouri, Ali
Boujelbane, Nouredine
Khabir, Abdelmajid
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aberrant hypermethylation of gene promoter regions is one of the mechanisms for inactivation of tumour suppressor genes in many human cancers including breast carcinoma.
In the current study, we aimed to assess by MSP, the methylation pattern of two cancer-related genes involved in DNA repair: hMLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2 (E.
coli) and BRCA1 (breast cancer 1, early onset) in 78 primary breast cancers from Tunisian patients.
The methylation frequencies were 24.36% for hMLH1 and 46% for BRCA1.
BRCA1 methylation correlated with age at diagnosis (P=.015) and 5-years disease free survival (P=.016) while hMLH1 methylation was more frequent in larger tumors (P=.002) and in presence of distant metastasis (P=.004).
Furthermore, methylation of hMLH1 significantly correlated with high level of P53 expression (P=.006) and with overall survival (P=.015) suggesting that silencing of hMLH1 through aberrant promoter methylation could be used as a poor prognosis indicator in breast cancer.
American Psychological Association (APA)
Karray-Chouayekh, Sondes& Trifa, Fatma& Khabir, Abdelmajid& Boujelbane, Nouredine& Sellami-Boudawara, Tahia& Daoud, Jamel…[et al.]. 2009. Clinical Significance of Epigenetic Inactivation of hMLH1 and BRCA1 in Tunisian Patients with Invasive Breast Carcinoma. BioMed Research International،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988357
Modern Language Association (MLA)
Karray-Chouayekh, Sondes…[et al.]. Clinical Significance of Epigenetic Inactivation of hMLH1 and BRCA1 in Tunisian Patients with Invasive Breast Carcinoma. BioMed Research International No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-988357
American Medical Association (AMA)
Karray-Chouayekh, Sondes& Trifa, Fatma& Khabir, Abdelmajid& Boujelbane, Nouredine& Sellami-Boudawara, Tahia& Daoud, Jamel…[et al.]. Clinical Significance of Epigenetic Inactivation of hMLH1 and BRCA1 in Tunisian Patients with Invasive Breast Carcinoma. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988357