The Phytoestrogen Quercetin Impairs Steroidogenesis and Angiogenesis in Swine Granulosa Cells In Vitro
Joint Authors
Bussolati, Simona
Santini, Sujen Eleonora
Basini, Giuseppina
Grasselli, Francesca
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Experimental evidence documents that nutritional phytoestrogens may interact with reproductive functions but the exact mechanism of action is still controversial.
Since quercetin is one of the main flavonoids in livestock nutrition, we evaluated its possible effects on cultured swine granulosa cell proliferation, steroidogenesis, and redox status.
Moreover, since angiogenesis is essential for follicle development, the effect of the flavonoid on Vascular Endothelial Growth Factor output by granulosa cells was also taken into account.
Our data evidence that quercetin does not affect granulosa cell growth while it inhibits progesterone production and modifies estradiol 17β production in a dose-related manner.
Additionally, the flavonoid interferes with the angiogenic process by inhibiting VEGF production as well as by altering redox status.
Since steroidogenesis and angiogenesis are strictly involved in follicular development, these findings appear particularly relevant, pointing out a possible negative influence of quercetin on ovarian physiology.
Therefore, the possible reproductive impact of the flavonoid should be carefully considered in animal nutrition.
American Psychological Association (APA)
Santini, Sujen Eleonora& Basini, Giuseppina& Bussolati, Simona& Grasselli, Francesca. 2009. The Phytoestrogen Quercetin Impairs Steroidogenesis and Angiogenesis in Swine Granulosa Cells In Vitro. BioMed Research International،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-988368
Modern Language Association (MLA)
Santini, Sujen Eleonora…[et al.]. The Phytoestrogen Quercetin Impairs Steroidogenesis and Angiogenesis in Swine Granulosa Cells In Vitro. BioMed Research International No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-988368
American Medical Association (AMA)
Santini, Sujen Eleonora& Basini, Giuseppina& Bussolati, Simona& Grasselli, Francesca. The Phytoestrogen Quercetin Impairs Steroidogenesis and Angiogenesis in Swine Granulosa Cells In Vitro. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-988368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988368