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Molecularly Characterised Xenograft Tumour Mouse Models: Valuable Tools for Evaluation of New Therapeutic Strategies for Secondary Liver Cancers
Joint Authors
Mischek, Daniela
Steinborn, Ralf
Petznek, Helga
Bichler, Christoph
Zatloukal, Kurt
Stürzl, Michael
Günzburg, Walter H.
Hohenadl, Christine
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To develop and evaluate new therapeutic strategies for the treatment of human cancers, well-characterised preclinical model systems are a prerequisite.
To this aim, we have established xenotransplantation mouse models and corresponding cell cultures from surgically obtained secondary human liver tumours.
Established xenograft tumours were patho- and immunohistologically characterised, and expression levels of cancer-relevant genes were quantified in paired original and xenograft tumours and the derivative cell cultures applying RT-PCR-based array technology.
Most of the characteristic morphological and immunohistochemical features of the original tumours were shown to be maintained.
No differences were found concerning expression of genes involved in cell cycle regulation and oncogenesis.
Interestingly, cytokine and matrix metalloproteinase encoding genes appeared to be expressed differentially.
Thus, the established models are closely reflecting pathohistological and molecular characteristics of the selected human tumours and may therefore provide useful tools for preclinical analyses of new antitumour strategies in vivo.
American Psychological Association (APA)
Mischek, Daniela& Steinborn, Ralf& Petznek, Helga& Bichler, Christoph& Zatloukal, Kurt& Stürzl, Michael…[et al.]. 2009. Molecularly Characterised Xenograft Tumour Mouse Models: Valuable Tools for Evaluation of New Therapeutic Strategies for Secondary Liver Cancers. BioMed Research International،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-988371
Modern Language Association (MLA)
Mischek, Daniela…[et al.]. Molecularly Characterised Xenograft Tumour Mouse Models: Valuable Tools for Evaluation of New Therapeutic Strategies for Secondary Liver Cancers. BioMed Research International No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-988371
American Medical Association (AMA)
Mischek, Daniela& Steinborn, Ralf& Petznek, Helga& Bichler, Christoph& Zatloukal, Kurt& Stürzl, Michael…[et al.]. Molecularly Characterised Xenograft Tumour Mouse Models: Valuable Tools for Evaluation of New Therapeutic Strategies for Secondary Liver Cancers. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-988371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988371