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Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia
Joint Authors
Chen, Xing
Liu, Wenmin
Chen, Gang
Zhou, Peng
Zhu, Haining
Luan, Meng
O'Donovan, Michael C.
Kirov, George
Williams, Nigel M.
Norton, Nadine
Yang, Shulin
Liu, Yang
Carroll, Liam
Owen, Michael J.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
DNA pooling can provide an economic and efficient way to detect susceptibility loci to complex diseases.
We carried out a genome screen with 400 microsatellite markers spaced at approximately 10 cm in two DNA pools consisting of 119 schizophrenia (SZ) patients and 119 controls recruited from a homogenous population in the Chang Le area of the Shandong peninsula of China.
Association of D6S289, a dinucleotide repeat polymorphism in the JARID2 gene with SZ, was found and confirmed by individual genotyping (X2=17.89; P=.047).
In order to refine the signal, we genotyped 14 single nucleotide polymorphisms (SNPs) covering JARID2 and the neighboring gene, DNTBP1, in an extended sample of 309 cases and 309 controls from Shandong peninsula (including the samples from the pools).
However, rs2235258 and rs9654600 in JARID2 showed association in allelic, genotypic and haplotypic tests with SZ patients from Chang Le area.
This was not replicates in the extended sample, we conclude that JARID2 could be a susceptibility gene for SZ.
American Psychological Association (APA)
Liu, Yang& Chen, Gang& Norton, Nadine& Liu, Wenmin& Zhu, Haining& Zhou, Peng…[et al.]. 2009. Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia. BioMed Research International،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988389
Modern Language Association (MLA)
Liu, Yang…[et al.]. Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia. BioMed Research International No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-988389
American Medical Association (AMA)
Liu, Yang& Chen, Gang& Norton, Nadine& Liu, Wenmin& Zhu, Haining& Zhou, Peng…[et al.]. Whole Genome Association Study in a Homogenous Population in Shandong Peninsula of China Reveals JARID2 as a Susceptibility Gene for Schizophrenia. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-988389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988389