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Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer
Joint Authors
Milecki, Piotr
Baczyk, Maciej
Kwias, Zbigniew
Martenka, Piotr
Antczak, Andrzej
Skowronek, Janusz
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To study whether use of neoadjuvant androgen deprivation therapy (N-ADT) combined with whole pelvic radiotherapy (WPRT) for high-risk prostate cancer patients was associated with survival benefit over prostate radiotherapy (PORT) only.
Material and Methods.
Between 1999 and 2004, 162 high-risk prostate cancer patients were treated with radiotherapy combined with long-term androgen deprivation therapy (L-ADT).
Patients were prospectively assigned into two groups: A (N-ADT + WPRT + L-ADT) n = 70 pts, B (PORT + L-ADT) n = 92 pts.
Results.
The 5-year actuarial overall survival (OS) rates were 89% for A and 78% for B (P = .13).
The 5-year actuarial cause specific survival (CSS) rates were A = 90% and B = 79% (P = .01).
Biochemical progression-free survival (bPFS) rates were 52% versus 40% (P = .07), for groups A and B, respectively.
Conclusions.
The WPRT combined with N-ADT compared to PORT for high-risk patients resulted in improvement in CSS and bPFS; however no OS benefit was observed.
American Psychological Association (APA)
Milecki, Piotr& Baczyk, Maciej& Skowronek, Janusz& Antczak, Andrzej& Kwias, Zbigniew& Martenka, Piotr. 2009. Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer. BioMed Research International،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-988416
Modern Language Association (MLA)
Milecki, Piotr…[et al.]. Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer. BioMed Research International No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-988416
American Medical Association (AMA)
Milecki, Piotr& Baczyk, Maciej& Skowronek, Janusz& Antczak, Andrzej& Kwias, Zbigniew& Martenka, Piotr. Benefit of Whole Pelvic Radiotherapy Combined with Neoadjuvant Androgen Deprivation for the High-Risk Prostate Cancer. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-988416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988416