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Integrating Multiple Microarray Data for Cancer Pathway Analysis Using Bootstrapping K-S Test
Joint Authors
Chen, Xue-Wen
Han, Bing
Michaelis, Elias K.
Wang, Xinkun
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Previous applications of microarray technology for cancer research have mostly focused on identifying genes that are differentially expressed between a particular cancer and normal cells.
In a biological system, genes perform different molecular functions and regulate various biological processes via interactions with other genes thus forming a variety of complex networks.
Therefore, it is critical to understand the relationship (e.g., interactions) between genes across different types of cancer in order to gain insights into the molecular mechanisms of cancer.
Here we propose an integrative method based on the bootstrapping Kolmogorov-Smirnov test and a large set of microarray data produced with various types of cancer to discover common molecular changes in cells from normal state to cancerous state.
We evaluate our method using three key pathways related to cancer and demonstrate that it is capable of finding meaningful alterations in gene relations.
American Psychological Association (APA)
Han, Bing& Chen, Xue-Wen& Wang, Xinkun& Michaelis, Elias K.. 2009. Integrating Multiple Microarray Data for Cancer Pathway Analysis Using Bootstrapping K-S Test. BioMed Research International،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988430
Modern Language Association (MLA)
Han, Bing…[et al.]. Integrating Multiple Microarray Data for Cancer Pathway Analysis Using Bootstrapping K-S Test. BioMed Research International No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-988430
American Medical Association (AMA)
Han, Bing& Chen, Xue-Wen& Wang, Xinkun& Michaelis, Elias K.. Integrating Multiple Microarray Data for Cancer Pathway Analysis Using Bootstrapping K-S Test. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988430