A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples
Joint Authors
Apostu, Mihai
Bibire, Nela
Vlase, Aurel
Oniscu, Corneliu
Peste, Gabriela
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Liquid chromatography (LC) coupled with mass spectrometry (MS) detection is one of the most powerful analytical tools for organic compound analysis.
The advantages of using LC/MS methods over HPLC methods include: selectivity, chromatographic integrity, peak assignment, structural information, and rapid method development.
In this paper, a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of bisoprolol in human plasma samples, using metoprolol as internal standard and liquid-liquid extraction procedure.
The assay has proven to be sensitive, specific and reproducible, suitable to determine the bisoprolol concentration, following a single oral administration of a 10 mg bisoprolol tablet in 22 healthy volunteers, in the bioequivalence study of Bisoprolol 10 mg coated tablets, produced by Antibiotice S.A.
versus Concor 10 mg, produced by Merck.
American Psychological Association (APA)
Peste, Gabriela& Bibire, Nela& Apostu, Mihai& Vlase, Aurel& Oniscu, Corneliu. 2009. A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples. BioMed Research International،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-988436
Modern Language Association (MLA)
Peste, Gabriela…[et al.]. A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples. BioMed Research International No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-988436
American Medical Association (AMA)
Peste, Gabriela& Bibire, Nela& Apostu, Mihai& Vlase, Aurel& Oniscu, Corneliu. A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-988436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988436