50Hz Extremely Low Frequency Electromagnetic Fields Enhance Protein Carbonyl Groups Content in Cancer Cells: Effects on Proteasomal Systems
Joint Authors
Cuccioloni, M.
Fioretti, E.
Cecarini, V.
Eleuteri, A. M.
Grimaldi, S.
Giuliani, L.
Amici, M.
Bonfili, L.
Angeletti, M.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Electromagnetic fields are an assessed cause of prolonging free radicals lifespan.
This study was carried out to investigate the influence of extremely low frequency electromagnetic fields on protein oxidation and on the 20S proteasome functionality, the complex responsible for the degradation of oxidized proteins.
Caco 2 cells were exposed, for 24–72 hours, to 1 mT, 50 Hz electromagnetic fields.
The treatment induced a time-dependent increase both in cell growth and in protein oxidation, more evident in the presence of TPA, while no changes in cell viability were detected.
Exposing the cells to 50 Hz electromagnetic fields caused a global activation of the 20S proteasome catalytic components, particularly evident at 72 hours exposure and in the presence of TPA.
The finding that EGCG, a natural antioxidant compound, counteracted the field-related pro-oxidant effects demonstrates that the increased proteasome activity was due to an enhancement in intracellular free radicals.
American Psychological Association (APA)
Eleuteri, A. M.& Amici, M.& Bonfili, L.& Cecarini, V.& Cuccioloni, M.& Grimaldi, S.…[et al.]. 2009. 50Hz Extremely Low Frequency Electromagnetic Fields Enhance Protein Carbonyl Groups Content in Cancer Cells: Effects on Proteasomal Systems. BioMed Research International،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988456
Modern Language Association (MLA)
Eleuteri, A. M.…[et al.]. 50Hz Extremely Low Frequency Electromagnetic Fields Enhance Protein Carbonyl Groups Content in Cancer Cells: Effects on Proteasomal Systems. BioMed Research International No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-988456
American Medical Association (AMA)
Eleuteri, A. M.& Amici, M.& Bonfili, L.& Cecarini, V.& Cuccioloni, M.& Grimaldi, S.…[et al.]. 50Hz Extremely Low Frequency Electromagnetic Fields Enhance Protein Carbonyl Groups Content in Cancer Cells: Effects on Proteasomal Systems. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988456