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Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis
Joint Authors
Liu, Shyun-Yeu
Chang, Hsueh-Wei
Lu, Min-Chi
Huang, Jia-Yan
Yen, Ching-Yu
Li, Ching
Liu, Shih-Tung
Chen, Ruey-Shyang
Shieh, Biehuoy
Tzeng, Ching-Cherng
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Epstein-Barr virus is known to cause nasopharyngeal carcinoma.
Although oral cavity is located close to the nasal pharynx, the pathogenetic role of Epstein-Barr virus (EBV) in oral cancers is unclear.
This molecular epidemiology study uses EBV genomic microarray (EBV-chip) to simultaneously detect the prevalent rate and viral gene expression patterns in 57 oral squamous cell carcinoma biopsies (OSCC) collected from patients in Taiwan.
The majority of the specimens (82.5%) were EBV-positive that probably expressed coincidently the genes for EBNAs, LMP2A and 2B, and certain structural proteins.
Importantly, the genes fabricated at the spots 61 (BBRF1, BBRF2, and BBRF3) and 68 (BDLF4 and BDRF1) on EBV-chip were actively expressed in a significantly greater number of OSCC exhibiting exophytic morphology or ulceration than those tissues with deep invasive lesions (P=.0265 and .0141, resp.).
The results may thus provide the lead information for understanding the role of EBV in oral cancer pathogenesis.
American Psychological Association (APA)
Yen, Ching-Yu& Lu, Min-Chi& Tzeng, Ching-Cherng& Huang, Jia-Yan& Chang, Hsueh-Wei& Chen, Ruey-Shyang…[et al.]. 2009. Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis. BioMed Research International،Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-988469
Modern Language Association (MLA)
Yen, Ching-Yu…[et al.]. Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis. BioMed Research International No. 2009 (2009), pp.1-15.
https://search.emarefa.net/detail/BIM-988469
American Medical Association (AMA)
Yen, Ching-Yu& Lu, Min-Chi& Tzeng, Ching-Cherng& Huang, Jia-Yan& Chang, Hsueh-Wei& Chen, Ruey-Shyang…[et al.]. Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-988469
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988469