Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats
Joint Authors
Tian, Ying
Jin, Xingming
Shen, Xiaoming
Yan, Chonghuai
Li, Fei
Zhang, Yuanyuan
Cao, Xiaohua
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate the influence of forepaw sensorimotor deprivation on memory and synaptic plasticity, Sprague-Dawley rats were divided into two groups: a sham-operated group and a group deprived of forepaw sensorimotor function by microsurgical operation at postnatal day 13 (PN13).
Behavioral and electrophysiological studies were performed at PN25, PN35, PN45, and PN60.
Open field test was used to assess the spontaneous locomotor activity.
Morris water maze was used to evaluate spatial reference learning and memory.
The long-term potentiation (LTP) in the medial perforant path—dentate gyrus (MPP-DG) pathway was examined with hippocampal slices.
We found that forepaw sensorimotor deprivation did not affect spontaneous activity of the rats.
However, spatial reference learning and memory were significantly impaired in their early life (PN25, PN35, and PN45).
In accordance with the behavior results, LTP in MPP-DG pathway was significantly suppressed in their early life.
These data demonstrated that forepaw sensorimotor deprivation led to the impairments on spatial memory via inducing pronounced deficits in the MPP-DG pathway to exhibit LTP, one of the major cellular mechanisms underlying learning and memory.
American Psychological Association (APA)
Zhang, Yuanyuan& Li, Fei& Cao, Xiaohua& Jin, Xingming& Yan, Chonghuai& Tian, Ying…[et al.]. 2009. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats. BioMed Research International،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988476
Modern Language Association (MLA)
Zhang, Yuanyuan…[et al.]. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats. BioMed Research International No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-988476
American Medical Association (AMA)
Zhang, Yuanyuan& Li, Fei& Cao, Xiaohua& Jin, Xingming& Yan, Chonghuai& Tian, Ying…[et al.]. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on Spatial Memory and Synaptic Plasticity in Rats. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988476