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A New Caspase-8 Isoform Caspase-8s Increased Sensitivity to Apoptosis in Jurkat Cells
Joint Authors
Wang, Min
Rao, Qing
Xu, Zhifang
Wang, Jianxiang
Tang, Kejing
Liu, Bolin
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Caspase-8 is a key initiator of death receptor-induced apoptosis.
Here we report a novel short isoform of caspase-8 (caspase-8s), which encodes the first (Death Effector Domain) DED and part of the second DED, missing the C-terminal caspase domain.
In vivo binding assays showed that transfected caspase-8s bound to (Fas-associated death domain protein) FADD, the adaptor protein in (death-induced signal complex) DISC.
To investigate the potential effects of caspase-8s on cell apoptosis, Jurkat cells were stably transfected with caspase-8s.
Overexpression of caspase-8s increased sensitivity to the apoptotic stimuli, Fas-agonistic antibody CH11.
These results suggest that caspase-8s may act as a promoter of apoptosis through binding to FADD and is involved in the regulation of apoptosis.
In addition, the results also indicate that the first DED was an important structure mediating combination between caspase-8 and FADD.
American Psychological Association (APA)
Xu, Zhifang& Tang, Kejing& Wang, Min& Rao, Qing& Liu, Bolin& Wang, Jianxiang. 2009. A New Caspase-8 Isoform Caspase-8s Increased Sensitivity to Apoptosis in Jurkat Cells. BioMed Research International،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988483
Modern Language Association (MLA)
Xu, Zhifang…[et al.]. A New Caspase-8 Isoform Caspase-8s Increased Sensitivity to Apoptosis in Jurkat Cells. BioMed Research International No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-988483
American Medical Association (AMA)
Xu, Zhifang& Tang, Kejing& Wang, Min& Rao, Qing& Liu, Bolin& Wang, Jianxiang. A New Caspase-8 Isoform Caspase-8s Increased Sensitivity to Apoptosis in Jurkat Cells. BioMed Research International. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988483