What Differs on the Enzymatic Acetylation Mechanisms for Arylamines and Arylhydrazines Substrates? A Theoretical Study
Joint Authors
Jing, Jie
Yang, Chuan-Lu
Cai, Zheng-Ting
Chen, Xin
Wang, Hua-Yang
Qiao, Qing-An
Sun, Xiao-Min
Source
Biochemistry Research International
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The acetylation mechanisms of several selected typical substrates from experiments, including arylamines and arylhydrazines, are investigated with the density functional theory in this paper.
The results indicate that all the transition states are characterized by a four-membered ring structure, and hydralazine (HDZ) is the most potent substrate.
The bioactivity for all the compounds is increased in a sequence of PABA≈4-AS<4-MA<5-AS≈INH The conjunction effect and the delocalization of the lone pairs of N atom play a key role in the reaction. All the results are consistent with the experimental data.
American Psychological Association (APA)
Qiao, Qing-An& Sun, Xiao-Min& Jing, Jie& Chen, Xin& Wang, Hua-Yang& Yang, Chuan-Lu…[et al.]. 2009. What Differs on the Enzymatic Acetylation Mechanisms for Arylamines and Arylhydrazines Substrates? A Theoretical Study. Biochemistry Research International،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988497
Modern Language Association (MLA)
Qiao, Qing-An…[et al.]. What Differs on the Enzymatic Acetylation Mechanisms for Arylamines and Arylhydrazines Substrates? A Theoretical Study. Biochemistry Research International No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-988497
American Medical Association (AMA)
Qiao, Qing-An& Sun, Xiao-Min& Jing, Jie& Chen, Xin& Wang, Hua-Yang& Yang, Chuan-Lu…[et al.]. What Differs on the Enzymatic Acetylation Mechanisms for Arylamines and Arylhydrazines Substrates? A Theoretical Study. Biochemistry Research International. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988497