Classification of Nonenzymatic Homologues of Protein Kinases
Joint Authors
Srinivasan, N.
Anamika, K.
Deshmukh, K.
Abhinandan, K. R.
Source
International Journal of Genomics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Protein Kinase-Like Non-kinases (PKLNKs), which are closely related to protein kinases, lack the crucial catalytic aspartate in the catalytic loop, and hence cannot function as protein kinase, have been analysed.
Using various sensitive sequence analysis methods, we have recognized 82 PKLNKs from four higher eukaryotic organisms, namely, Homo sapiens, Mus musculus, Rattus norvegicus, and Drosophila melanogaster.
On the basis of their domain combination and function, PKLNKs have been classified mainly into four categories: (1) Ligand binding PKLNKs, (2) PKLNKs with extracellular protein-protein interaction domain, (3) PKLNKs involved in dimerization, and (4) PKLNKs with cytoplasmic protein-protein interaction module.
While members of the first two classes of PKLNKs have transmembrane domain tethered to the PKLNK domain, members of the other two classes of PKLNKs are cytoplasmic in nature.
The current classification scheme hopes to provide a convenient framework to classify the PKLNKs from other eukaryotes which would be helpful in deciphering their roles in cellular processes.
American Psychological Association (APA)
Anamika, K.& Abhinandan, K. R.& Deshmukh, K.& Srinivasan, N.. 2009. Classification of Nonenzymatic Homologues of Protein Kinases. International Journal of Genomics،Vol. 2009, no. 2009, pp.1-17.
https://search.emarefa.net/detail/BIM-988520
Modern Language Association (MLA)
Anamika, K.…[et al.]. Classification of Nonenzymatic Homologues of Protein Kinases. International Journal of Genomics No. 2009 (2009), pp.1-17.
https://search.emarefa.net/detail/BIM-988520
American Medical Association (AMA)
Anamika, K.& Abhinandan, K. R.& Deshmukh, K.& Srinivasan, N.. Classification of Nonenzymatic Homologues of Protein Kinases. International Journal of Genomics. 2009. Vol. 2009, no. 2009, pp.1-17.
https://search.emarefa.net/detail/BIM-988520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988520