Evolutionary Conservation Levels of Subunits of Histone-Modifying Protein Complexes in Fungi
Author
Source
International Journal of Genomics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Eukaryotes possess a variety of histone-modifying protein complexes.
Generally, a histone-modifying protein complex consists of multiple subunits, that is, a catalytic subunit and the associated subunits.
In this study, I analyzed 62 and 48 subunits of the histone-modifying protein complexes of Saccharomyces cerevisiae and Schizosaccharomyces pombe, respectively.
The evolutionary conservation levels of the 110 subunits were measured.
The measurements revealed that the conservation levels of the catalytic subunits are significantly higher than those of the associated subunits of the histone acetyltransferase and deacetylase complexes; however, the conservation level of the catalytic subunits is similar to that of the associated subunits of the histone methyltransferase complexes.
Thus, in the fungal histone acetylation and deacetylation systems, the catalytic subunits of histone-modifying protein complexes are conserved and the associated subunits are evolutionary lineage-specific.
In contrast, in the fungal histone methylation system, both the catalytic and the associated subunits are evolutionary lineage-specific.
American Psychological Association (APA)
Nishida, Hiromi. 2009. Evolutionary Conservation Levels of Subunits of Histone-Modifying Protein Complexes in Fungi. International Journal of Genomics،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988521
Modern Language Association (MLA)
Nishida, Hiromi. Evolutionary Conservation Levels of Subunits of Histone-Modifying Protein Complexes in Fungi. International Journal of Genomics No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-988521
American Medical Association (AMA)
Nishida, Hiromi. Evolutionary Conservation Levels of Subunits of Histone-Modifying Protein Complexes in Fungi. International Journal of Genomics. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988521