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MicroRNA Profiling and Head and Neck Cancer
Joint Authors
Xia, James
Zhou, Xiaofeng
Yu, Jinsheng
Liu, Xiqiang
Chen, Zugen
Source
International Journal of Genomics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Head and neck/oral cancer (HNOC) is a devastating disease.
Despite advances in diagnosis and treatment, mortality rates have not improved significantly over the past three decades.
Improvement in patient survival requires a better understanding of the disease progression so that HNOC can be detected early in the disease process and targeted therapeutic interventions can be deployed.
Accumulating evidence suggests that microRNAs play important roles in many human cancers.
They are pivotal regulators of diverse cellular processes including proliferation, differentiation, apoptosis, survival, motility, and morphogenesis.
MicroRNA expression patterns may become powerful biomarkers for diagnosis and prognosis of HNOC.
In addition, microRNA therapy could be a novel strategy for HNOC prevention and therapeutics.
Recent advances in microRNA expression profiling have led to a better understanding of the cancer pathogenesis.
In this review, we will survey recent technological advances in microRNA profiling and their applications in defining microRNA markers/targets for cancer prediction, diagnostics, treatment, and prognostics.
MicroRNA alterations that consistently identified in HNOC will be discussed, such as upregulation of miR-21, miR-31, miR-155, and downregulation of miR-26b, miR-107, miR-133b, miR-138, and miR-139.
American Psychological Association (APA)
Liu, Xiqiang& Chen, Zugen& Yu, Jinsheng& Xia, James& Zhou, Xiaofeng. 2009. MicroRNA Profiling and Head and Neck Cancer. International Journal of Genomics،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988534
Modern Language Association (MLA)
Liu, Xiqiang…[et al.]. MicroRNA Profiling and Head and Neck Cancer. International Journal of Genomics No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-988534
American Medical Association (AMA)
Liu, Xiqiang& Chen, Zugen& Yu, Jinsheng& Xia, James& Zhou, Xiaofeng. MicroRNA Profiling and Head and Neck Cancer. International Journal of Genomics. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-988534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988534