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Glinide, but Not Sulfonylurea, Can Evoke Insulin Exocytosis by Repetitive Stimulation: Imaging Analysis of Insulin Exocytosis by Secretagogue-Induced Repetitive Stimulations
Joint Authors
Nishiwaki, Chiyono
Nakamichi, Yoko
Ohara-Imaizumi, Mica
Aoyagi, Kyota
Nagamatsu, Shinya
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To investigate the different effects between sulfonylurea (SU) and glinide drugs in insulin secretion, pancreatic β-cells were repeatedly stimulated with SU (glimepiride) or glinide (mitiglinide).
Total internal reflection fluorescent (TIRF) microscopy revealed that secondary stimulation with glimepiride, but not glucose and mitiglinide, failed to evoke fusions of insulin granules although primary stimulation with glucose, glimepiride, and mitiglinide induced equivalent numbers of exocytotic responses.
Glimepiride, but not glucose and mitiglinide, induced abnormally sustained [Ca2+]i elevations and reductions of docked insulin granules on the plasma membrane.
Our data suggest that the effect of glinide on insulin secretory mechanisms is similar to that of glucose.
American Psychological Association (APA)
Aoyagi, Kyota& Ohara-Imaizumi, Mica& Nishiwaki, Chiyono& Nakamichi, Yoko& Nagamatsu, Shinya. 2009. Glinide, but Not Sulfonylurea, Can Evoke Insulin Exocytosis by Repetitive Stimulation: Imaging Analysis of Insulin Exocytosis by Secretagogue-Induced Repetitive Stimulations. Journal of Diabetes Research،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988572
Modern Language Association (MLA)
Aoyagi, Kyota…[et al.]. Glinide, but Not Sulfonylurea, Can Evoke Insulin Exocytosis by Repetitive Stimulation: Imaging Analysis of Insulin Exocytosis by Secretagogue-Induced Repetitive Stimulations. Journal of Diabetes Research No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-988572
American Medical Association (AMA)
Aoyagi, Kyota& Ohara-Imaizumi, Mica& Nishiwaki, Chiyono& Nakamichi, Yoko& Nagamatsu, Shinya. Glinide, but Not Sulfonylurea, Can Evoke Insulin Exocytosis by Repetitive Stimulation: Imaging Analysis of Insulin Exocytosis by Secretagogue-Induced Repetitive Stimulations. Journal of Diabetes Research. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988572