Cold Exposure Exacerbates the Development of Diabetic Polyneuropathy in the Rat
Joint Authors
Gibbons, Christopher H.
Veves, Aristidis
Kasselman, Lora J.
Rutkove, Seward B.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic polyneuropathy (DPN) and cold-induced nerve injury share several pathogenic mechanisms.
This study explores whether cold exposure contributes to the development of DPN.
Streptozotocin-induced diabetic rats and controls were exposed to a room temperature (23∘C) or cold environment (10∘C).
H-reflex, tail and sciatic motor, and sensory nerve conduction studies were performed.
Analyses of sural nerve, intraepidermal nerve fibers, and skin and nerve nitrotyrosine ELISAs were performed.
Diabetic animals exposed to a cold environment had an increased H-reflex four weeks earlier than diabetic room temperature animals (P=.03).
Cold-exposed diabetic animals also had greater reduction in motor conduction velocities at 20 weeks (P=.017), decreased skin nerve fiber density (P=.037), and increased skin nitrotyrosine levels (P=.047).
Cold exposure appears to hasten the development of DPN in the rat STZ model of diabetes.
These findings support that further study into the relationship between ambient temperature and DPN is warranted.
American Psychological Association (APA)
Kasselman, Lora J.& Veves, Aristidis& Gibbons, Christopher H.& Rutkove, Seward B.. 2009. Cold Exposure Exacerbates the Development of Diabetic Polyneuropathy in the Rat. Journal of Diabetes Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988586
Modern Language Association (MLA)
Kasselman, Lora J.…[et al.]. Cold Exposure Exacerbates the Development of Diabetic Polyneuropathy in the Rat. Journal of Diabetes Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-988586
American Medical Association (AMA)
Kasselman, Lora J.& Veves, Aristidis& Gibbons, Christopher H.& Rutkove, Seward B.. Cold Exposure Exacerbates the Development of Diabetic Polyneuropathy in the Rat. Journal of Diabetes Research. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988586