Cancer Vaccine by Fusions of Dendritic and Cancer Cells
Joint Authors
Hara, Eiichi
Homma, Sadamu
Koido, Shigeo
Namiki, Yoshihisa
Ohkusa, Toshifumi
Gong, Jianlin
Tajiri, Hisao
Source
Journal of Immunology Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses.
Therefore, their use for the active immunotherapy against cancers has been studied with considerable interest.
The fusion of DCs with whole tumor cells represents in many ways an ideal approach to deliver, process, and subsequently present a broad array of tumor-associated antigens, including those yet to be unidentified, in the context of DCs-derived costimulatory molecules.
DCs/tumor fusion vaccine stimulates potent antitumor immunity in the animal tumor models.
In the human studies, T cells stimulated by DC/tumor fusion cells are effective in lysis of tumor cells that are used as the fusion partner.
In the clinical trials, clinical and immunological responses were observed in patients with advanced stage of malignant tumors after being vaccinated with DC/tumor fusion cells, although the antitumor effect is not as vigorous as in the animal tumor models.
This review summarizes recent advances in concepts and techniques that are providing new impulses to DCs/tumor fusions-based cancer vaccination.
American Psychological Association (APA)
Koido, Shigeo& Hara, Eiichi& Homma, Sadamu& Namiki, Yoshihisa& Ohkusa, Toshifumi& Gong, Jianlin…[et al.]. 2010. Cancer Vaccine by Fusions of Dendritic and Cancer Cells. Journal of Immunology Research،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-988617
Modern Language Association (MLA)
Koido, Shigeo…[et al.]. Cancer Vaccine by Fusions of Dendritic and Cancer Cells. Journal of Immunology Research No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-988617
American Medical Association (AMA)
Koido, Shigeo& Hara, Eiichi& Homma, Sadamu& Namiki, Yoshihisa& Ohkusa, Toshifumi& Gong, Jianlin…[et al.]. Cancer Vaccine by Fusions of Dendritic and Cancer Cells. Journal of Immunology Research. 2010. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-988617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988617