The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRLlpr Mice
Joint Authors
Yoshimasu, Takashi
Mikita, Naoya
Yamamoto, Yuki
Kanazawa, Nobuo
Ikeda, Takaharu
Furukawa, Fukumi
Li, Hong-jin
Source
Journal of Immunology Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated the effects of ultraviolet A1 (UVA1) irradiation on spontaneous lupus erythematosus- (LE-) like skin lesions of MRL/lpr mice, using a disease prevention model.
UVA1 irradiation significantly inhibited the development of LE-like skin lesions, without obvious changes of the disease including renal disease and serum antinuclear antibody levels.
Besides the massive infiltration of mast cells in the LE-like skin lesions, in the nonlesional skins, more mast cells infiltrated in the UVA1-irradiated group compared with the nonirradiated group.
Although apoptotic cells were remarkably seen in the dermis of UVA1-irradiated mice, those cells were hardly detectable in the dermis of the nonirradiated mice without skin lesions.
Further analysis showed that some of those apoptotic cells were mast cells.
Thus, UVA1 might exert its effects, at least in part, through the induction of the apoptosis of pathogenic mast cells.
Our results supported the clinical efficacy of UVA1 irradiation for skin lesions of lupus patients.
American Psychological Association (APA)
Mikita, Naoya& Kanazawa, Nobuo& Yoshimasu, Takashi& Ikeda, Takaharu& Li, Hong-jin& Yamamoto, Yuki…[et al.]. 2009. The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRLlpr Mice. Journal of Immunology Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988618
Modern Language Association (MLA)
Mikita, Naoya…[et al.]. The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRLlpr Mice. Journal of Immunology Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-988618
American Medical Association (AMA)
Mikita, Naoya& Kanazawa, Nobuo& Yoshimasu, Takashi& Ikeda, Takaharu& Li, Hong-jin& Yamamoto, Yuki…[et al.]. The Protective Effects of Ultraviolet A1 Irradiation on Spontaneous Lupus Erythematosus-Like Skin Lesions in MRLlpr Mice. Journal of Immunology Research. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988618