Mizoribine: A New Approach in the Treatment of Renal Disease
Author
Source
Journal of Immunology Research
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mizoribine (MZB) is an imidazole nucleoside and an immunosuppressive agent.
The immunosuppressive effect of MZB has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle.
Because of its relative lack of toxicity, during the past decade MZB has been frequently used instead of azathioprine as a component of immunosuppressive drug regimens.
MZB is being used to treat renal transplantation patients, IgA nephropathy, lupus erythematosus, and childhood nephrotic syndrome (NS), and some recent studies have assessed the efficacy of oral MZB pulse therapy for severe lupus nephritis, steroid-resistant NS, and frequently relapsing-steroid-dependent NS.
This review summarizes the published findings on the efficacy of MZB for renal disease including IgA nephropathy, lupus nephritis, and NS, as well as of oral MZB pulse therapy for severe lupus nephritis and NS, and also the mechanism of the effect of oral MZB pulse therapy on the lymphocyte cell cycle.
American Psychological Association (APA)
Kawasaki, Yukihiko. 2009. Mizoribine: A New Approach in the Treatment of Renal Disease. Journal of Immunology Research،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988620
Modern Language Association (MLA)
Kawasaki, Yukihiko. Mizoribine: A New Approach in the Treatment of Renal Disease. Journal of Immunology Research No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-988620
American Medical Association (AMA)
Kawasaki, Yukihiko. Mizoribine: A New Approach in the Treatment of Renal Disease. Journal of Immunology Research. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988620