Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPARγ)
Joint Authors
Randall, Michael D.
Kendall, David A.
O'Sullivan, Saoirse E.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the present study was to examine whether endocannabinoids cause PPARγ-mediated vascular actions.
Functional vascular studies were carried out in rat aortae.
Anandamide and N-arachidonoyl-dopamine (NADA), but not palmitoylethanolamide, caused significant vasorelaxation over time (2 hours).
Vasorelaxation to NADA, but not anandamide, was inhibited by CB1 receptor antagonism (AM251, 1 μM), and vasorelaxation to both anandamide and NADA was inhibited by PPARγ antagonism (GW9662, 1 μM).
Pharmacological inhibition of de novo protein synthesis, nitric oxide synthase, and super oxide dismutase abolished the responses to anandamide and NADA.
Removal of the endothelium partly inhibited the vasorelaxant responses to anandamide and NADA.
Inhibition of fatty acid amide hydrolase (URB597, 1 μM) inhibited the vasorelaxant response to NADA, but not anandamide.
These data indicate that endocannabinoids cause time-dependent, PPARγ-mediated vasorelaxation.
Activation of PPARγ in the vasculature may represent a novel mechanism by which endocannabinoids are involved in vascular regulation.
American Psychological Association (APA)
O'Sullivan, Saoirse E.& Kendall, David A.& Randall, Michael D.. 2009. Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPARγ). PPAR Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988642
Modern Language Association (MLA)
O'Sullivan, Saoirse E.…[et al.]. Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPARγ). PPAR Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-988642
American Medical Association (AMA)
O'Sullivan, Saoirse E.& Kendall, David A.& Randall, Michael D.. Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPARγ). PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-988642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988642