Outcomes of First-Line Chemotherapy in Patients with Advanced or Metastatic Leiomyosarcoma of Uterine and Non-Uterine Origin
Joint Authors
Verweij, J.
Sleijfer, S.
den Bakker, M. A.
Schmitz, P. I. M.
Seynaeve, C.
Oosten, A. W.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although leiomyosarcomas (LMSs) form the largest subgroup of soft tissue sarcomas (STSs), the efficacy of chemotherapy in this group is largely unclear, partly because older studies are contaminated with gastrointestinal stromal tumors (GISTs).
In this retrospective study we investigated the outcome of first line chemotherapy in 65 patients with unresectable or metastatic LMS.
The overall response rate (ORR) was 18%; and the median progression-free (PFS) and overall survival (OS) were 3.8 and 9.7 months respectively.
No statistically significant differences in outcomes for uterine and non-uterine LMS were found.
In non-uterine LMS, however, the PFS and OS seemed to be longer for females than for males, potentially negatively affecting outcomes in this group.
If our observations are confirmed in other series, they would suggest that studies performed in STS patients should not only stratify for histological subtype but also for uterine versus non-uterine LMS and for gender.
American Psychological Association (APA)
Oosten, A. W.& Seynaeve, C.& Schmitz, P. I. M.& den Bakker, M. A.& Verweij, J.& Sleijfer, S.. 2009. Outcomes of First-Line Chemotherapy in Patients with Advanced or Metastatic Leiomyosarcoma of Uterine and Non-Uterine Origin. Complexity،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988644
Modern Language Association (MLA)
Oosten, A. W.…[et al.]. Outcomes of First-Line Chemotherapy in Patients with Advanced or Metastatic Leiomyosarcoma of Uterine and Non-Uterine Origin. Complexity No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-988644
American Medical Association (AMA)
Oosten, A. W.& Seynaeve, C.& Schmitz, P. I. M.& den Bakker, M. A.& Verweij, J.& Sleijfer, S.. Outcomes of First-Line Chemotherapy in Patients with Advanced or Metastatic Leiomyosarcoma of Uterine and Non-Uterine Origin. Complexity. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-988644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988644