Primary Adult Renal Ewing's Sarcoma: A Rare Entity
Joint Authors
Judson, Ian R.
Venkitaraman, Ramachandran
Mukkunda, Ravindra
Thway, Khin
Min, Toon
Horwich, Alan
Fisher, Cyril
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Ewing's sarcoma of extraskeletal origin is uncommon and that is of primary renal origin in adults are rare.
There is no consensus on the optimal management of Ewing's tumors of renal origin.
Methods.
A retrospective review of the clinical features, treatment, and outcome of adult patients with primary renal extra-skeletal Ewing's sarcoma who were treated at the Royal Marsden hospital from January 1993–December 2007 is reported.
Results.
Seven adult patients with primary renal Ewing's sarcoma were identified.
All four patients with nonmetastatic disease had radical nephrectomy and received adjuvant chemotherapy +/− radiotherapy.
Two developed metastatic disease while on adjuvant chemotherapy, and one patient relapsed after 55 months.
The three patients with metastatic disease at presentation did not have nephrectomy and were treated with chemotherapy.
All three patients had disease progression with a dismal outcome.
Only one patient in the whole group is alive and disease free.
The median overall survival was 62.8 months, and the median disease-free survival in patients with nonmetastatic disease after combined modality treatment was 30.3 months.
Conclusion.
Primary adult renal Ewing's sarcoma is an aggressive tumor with a propensity for early metastasis.
Radical nephrectomy with adjuvant combination chemotherapy produced the best results but the outlook remained poor with only one patient experiencing long disease-free survival.
American Psychological Association (APA)
Mukkunda, Ravindra& Venkitaraman, Ramachandran& Thway, Khin& Min, Toon& Fisher, Cyril& Horwich, Alan…[et al.]. 2009. Primary Adult Renal Ewing's Sarcoma: A Rare Entity. Complexity،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988648
Modern Language Association (MLA)
Mukkunda, Ravindra…[et al.]. Primary Adult Renal Ewing's Sarcoma: A Rare Entity. Complexity No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-988648
American Medical Association (AMA)
Mukkunda, Ravindra& Venkitaraman, Ramachandran& Thway, Khin& Min, Toon& Fisher, Cyril& Horwich, Alan…[et al.]. Primary Adult Renal Ewing's Sarcoma: A Rare Entity. Complexity. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-988648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988648