Synergism of Heat Shock Protein 90 and Histone Deacetylase Inhibitors in Synovial Sarcoma
Joint Authors
Nielsen, Torsten O.
Nguyen, Anne
Poulin, Neal M.
Su, Le
Campbell, Belinda
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Current systemic therapies have little curative benefit for synovial sarcoma.
Histone deacetylase (HDAC) inhibitors and the heat shock protein 90 (Hsp90) inhibitor 17-AAG have recently been shown to inhibit synovial sarcoma in preclinical models.
We tested combinations of 17-AAG with the HDAC inhibitor MS-275 for synergism by proliferation and apoptosis assays.
The combination was found to be synergistic at multiple time points in two synovial sarcoma cell lines.
Previous studies have shown that HDAC inhibitors not only induce cell death but also activate the survival pathway NF-κB, potentially limiting therapeutic benefit.
As 17-AAG inhibits activators of NF-κB, we tested if 17-AAG synergizes with MS-275 through abrogating NF-κB activation.
In our assays, adding 17-AAG blocks NF-κB activation by MS-275 and siRNA directed against histone deacetylase 3 (HDAC3) recapitulates the effects of MS-275.
Additionally, we find that the NF-κB inhibitor BAY 11-7085 synergizes with MS-275.
We conclude that agents inhibiting NF-κB synergize with HDAC inhibitors against synovial sarcoma.
American Psychological Association (APA)
Nguyen, Anne& Su, Le& Campbell, Belinda& Poulin, Neal M.& Nielsen, Torsten O.. 2009. Synergism of Heat Shock Protein 90 and Histone Deacetylase Inhibitors in Synovial Sarcoma. Complexity،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988657
Modern Language Association (MLA)
Nguyen, Anne…[et al.]. Synergism of Heat Shock Protein 90 and Histone Deacetylase Inhibitors in Synovial Sarcoma. Complexity No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-988657
American Medical Association (AMA)
Nguyen, Anne& Su, Le& Campbell, Belinda& Poulin, Neal M.& Nielsen, Torsten O.. Synergism of Heat Shock Protein 90 and Histone Deacetylase Inhibitors in Synovial Sarcoma. Complexity. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-988657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988657