Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis
Joint Authors
Nakagawa, Hiroshi
Nonoguchi, Naosuke
Miyatake, Shin-ichi
Hagiya, Yuichiro
Kuroiwa, Toshihiko
Ishikawa, Toshihisa
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Accumulating evidence indicates that ATP-binding cassette (ABC) transporter ABCG2 plays a key role in regulating the cellular accumulation of porphyrin derivatives in cancer cells and thereby affects the efficacy of photodynamic therapy and photodynamic diagnosis.
The activity of porphyrin efflux can be affected by genetic polymorphisms in the ABCG2 gene.
On the other hand, Nrf2, an NF-E2-related transcription factor, has been shown to be involved in oxidative stress-mediated induction of the ABCG2 gene.
Since patients have demonstrated individual differences in their response to photodynamic therapy, transcriptional activation and/or genetic polymorphisms of the ABCG2 gene in cancer cells may affect patients' responses to photodynamic therapy.
Protein kinase inhibitors, including imatinib mesylate and gefitinib, are suggested to potentially enhance the efficacy of photodynamic therapy by blocking ABCG2-mediated porphyrin efflux from cancer cells.
This review article provides an overview on the role of human ABC transporter ABCG2 in photodynamic therapy and photodynamic diagnosis.
American Psychological Association (APA)
Ishikawa, Toshihisa& Nakagawa, Hiroshi& Hagiya, Yuichiro& Nonoguchi, Naosuke& Miyatake, Shin-ichi& Kuroiwa, Toshihiko. 2010. Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-988672
Modern Language Association (MLA)
Ishikawa, Toshihisa…[et al.]. Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis. Advances in Pharmacological and Pharmaceutical Sciences No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-988672
American Medical Association (AMA)
Ishikawa, Toshihisa& Nakagawa, Hiroshi& Hagiya, Yuichiro& Nonoguchi, Naosuke& Miyatake, Shin-ichi& Kuroiwa, Toshihiko. Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis. Advances in Pharmacological and Pharmaceutical Sciences. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-988672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988672