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Leishmania Interferes with Host Cell Signaling to Devise a Survival Strategy
Joint Authors
Srivastava, Neetu
Saha, Bhaskar
Sudan, Raki
Bhardwaj, Suvercha
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The protozoan parasite Leishmania spp.
exists as extracellular promastigotes in its vector whereas it resides and replicates as amastigotes within the macrophages of its mammalian host.
As a survival strategy, Leishmania modulates macrophage functions directly or indirectly.
The direct interference includes prevention of oxidative burst and the effector functions that lead to its elimination.
The indirect effects include the antigen presentation and modulation of T cell functions in such a way that the effector T cells help the parasite survive by macrophage deactivation.
Most of these direct and indirect effects are regulated by host cell receptor signaling that occurs through cycles of phosphorylation and dephosphorylation in cascades of kinases and phosphatases.
This review highlights how Leishmania selectively manipulates the different signaling pathways to ensure its survival.
American Psychological Association (APA)
Bhardwaj, Suvercha& Srivastava, Neetu& Sudan, Raki& Saha, Bhaskar. 2010. Leishmania Interferes with Host Cell Signaling to Devise a Survival Strategy. BioMed Research International،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-988754
Modern Language Association (MLA)
Bhardwaj, Suvercha…[et al.]. Leishmania Interferes with Host Cell Signaling to Devise a Survival Strategy. BioMed Research International No. 2010 (Dec. 2010), pp.1-13.
https://search.emarefa.net/detail/BIM-988754
American Medical Association (AMA)
Bhardwaj, Suvercha& Srivastava, Neetu& Sudan, Raki& Saha, Bhaskar. Leishmania Interferes with Host Cell Signaling to Devise a Survival Strategy. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-988754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988754