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Clinical Relevance of KRAS in Human Cancers
Joint Authors
Hajdúch, Marián
Drábek, Jiří
Jančík, Sylwia
Radzioch, Danuta
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The KRAS gene (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that encodes a small GTPase transductor protein called KRAS.
KRAS is involved in the regulation of cell division as a result of its ability to relay external signals to the cell nucleus.
Activating mutations in the KRAS gene impair the ability of the KRAS protein to switch between active and inactive states, leading to cell transformation and increased resistance to chemotherapy and biological therapies targeting epidermal growth factor receptors.
This review highlights some of the features of the KRAS gene and the KRAS protein and summarizes current knowledge of the mechanism of KRAS gene regulation.
It also underlines the importance of activating mutations in the KRAS gene in relation to carcinogenesis and their importance as diagnostic biomarkers, providing clues regarding human cancer patients' prognosis and indicating potential therapeutic approaches.
American Psychological Association (APA)
Jančík, Sylwia& Drábek, Jiří& Radzioch, Danuta& Hajdúch, Marián. 2010. Clinical Relevance of KRAS in Human Cancers. BioMed Research International،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-988781
Modern Language Association (MLA)
Jančík, Sylwia…[et al.]. Clinical Relevance of KRAS in Human Cancers. BioMed Research International No. 2010 (Dec. 2010), pp.1-13.
https://search.emarefa.net/detail/BIM-988781
American Medical Association (AMA)
Jančík, Sylwia& Drábek, Jiří& Radzioch, Danuta& Hajdúch, Marián. Clinical Relevance of KRAS in Human Cancers. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-988781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988781