Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury
Joint Authors
Wang, Junping
Su, Yongping
Shi, Chunmeng
Ran, Xinze
Dong, Shiwu
Liu, Dengqun
Li, Chunxue
Zou, Zhongmin
Wang, Fengchao
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Interstitial cells of Cajal (ICCs) in gastrointestinal tract are specialized cells serving as pacemaker cells.
The origin of ICCs is currently not fully characterized.
In this work, we aimed to study whether bone marrow-derived cells (BMDCs) could contribute to the origin of ICCs in the muscular plexus of small intestine using GFP-C57BL/6 chimeric mice.Engraftment of BMDCs in the intestine was investigated for GFP expression.
GFP positive bone marrow mononuclear cells reached a proportion of 95.65%±3.72% at different times in chimerism.
Donor-derived cells distributed widely in all the layers of the gastrointestinal tract.
There were GFP positive BMDCs in the myenteric plexus, which resembled characteristics of ICCs, including myenteric location, c-Kit positive staining, and ramified morphology.
Donor-derived ICCs in the myenteric plexus contributed to a percentage ranging 9.25%±4.9% of all the ICCs in the myenteric plexus.
In conclusion, here we described that donor-derived BMDCs might differentiate into gastrointestinal ICCs after radiation injury, which provided an alternative source for the origin of the ICCs in the muscular plexus of adult intestine.
These results further identified the plasticity of BMDCs and indicated therapeutic implications of BMDCs for the gastrointestinal dysmotility caused by ICCs disorders.
American Psychological Association (APA)
Liu, Dengqun& Wang, Fengchao& Zou, Zhongmin& Dong, Shiwu& Wang, Junping& Ran, Xinze…[et al.]. 2010. Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-988784
Modern Language Association (MLA)
Liu, Dengqun…[et al.]. Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-988784
American Medical Association (AMA)
Liu, Dengqun& Wang, Fengchao& Zou, Zhongmin& Dong, Shiwu& Wang, Junping& Ran, Xinze…[et al.]. Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-988784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988784