Cysteine-Free Proteins in the Immunobiology of Arthropod-Borne Diseases
Joint Authors
Mejia, J. Santiago
Titus, Richard G.
Arthun, Erik N.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
One approach to identify epitopes that could be used in the design of vaccines to control several arthropod-borne diseases simultaneously is to look for common structural features in the secretome of the pathogens that cause them.
Using a novel bioinformatics technique, cysteine-abundance and distribution analysis, we found that many different proteins secreted by several arthropod-borne pathogens, including Plasmodium falciparum, Borrelia burgdorferi, and eight species of Proteobacteria, are devoid of cysteine residues.
The identification of three cysteine-abundance and distribution patterns in several families of proteins secreted by pathogenic and nonpathogenic Proteobacteria, and not found when the amino acid analyzed was tryptophan, provides evidence of forces restricting the content of cysteine residues in microbial proteins during evolution.
We discuss these findings in the context of protein structure and function, antigenicity and immunogenicity, and host-parasite relationships.
American Psychological Association (APA)
Mejia, J. Santiago& Arthun, Erik N.& Titus, Richard G.. 2009. Cysteine-Free Proteins in the Immunobiology of Arthropod-Borne Diseases. BioMed Research International،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-988789
Modern Language Association (MLA)
Mejia, J. Santiago…[et al.]. Cysteine-Free Proteins in the Immunobiology of Arthropod-Borne Diseases. BioMed Research International No. 2010 (Dec. 2010), pp.1-10.
https://search.emarefa.net/detail/BIM-988789
American Medical Association (AMA)
Mejia, J. Santiago& Arthun, Erik N.& Titus, Richard G.. Cysteine-Free Proteins in the Immunobiology of Arthropod-Borne Diseases. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-988789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988789