Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8
Joint Authors
Kim, Sang Hoon
Lee, Ji-Yeon
Deocaris, Custer C.
Min, Hyehyun
Chung, Hyun Joo
Kim, Myoung Hee
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Using a ChIP-cloning technique, we identified a Zinc finger protein 804a (Zfp804a) as one of the putative Hoxc8 downstream target genes.
We confirmed binding of Hoxc8 to an intronic region of Zfp804a by ChIP-PCR in F9 cells as well as in mouse embryos.
Hoxc8 upregulated Zfp804a mRNA levels and augmented minimal promoter activity in vitro.
In E11.5 mouse embryos, Zfp804a and Hoxc8 were coexpressed.
Recent genome-wide studies identified Zfp804a (or ZNF804A in humans) as a plausible marker for schizophrenia, leading us to hypothesize that this embryogenic regulatory control might also exert influence in development of complex traits such as psychosis.
American Psychological Association (APA)
Chung, Hyun Joo& Lee, Ji-Yeon& Deocaris, Custer C.& Min, Hyehyun& Kim, Sang Hoon& Kim, Myoung Hee. 2010. Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988814
Modern Language Association (MLA)
Chung, Hyun Joo…[et al.]. Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-988814
American Medical Association (AMA)
Chung, Hyun Joo& Lee, Ji-Yeon& Deocaris, Custer C.& Min, Hyehyun& Kim, Sang Hoon& Kim, Myoung Hee. Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988814
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988814