Biology by Design: From Top to Bottom and Back
Joint Authors
Leonard, Joshua N.
Jewett, Michael C.
Timmerman, Laura E.
Daringer, Nichole M.
Fritz, Brian R.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Synthetic biology is a nascent technical discipline that seeks to enable the design and construction of novel biological systems to meet pressing societal needs.
However, engineering biology still requires much trial and error because we lack effective approaches for connecting basic “parts” into higher-order networks that behave as predicted.
Developing strategies for improving the performance and sophistication of our designs is informed by two overarching perspectives: “bottom-up” and “top-down” considerations.
Using this framework, we describe a conceptual model for developing novel biological systems that function and interact with existing biological components in a predictable fashion.
We discuss this model in the context of three topical areas: biochemical transformations, cellular devices and therapeutics, and approaches that expand the chemistry of life.
Ten years after the construction of synthetic biology's first devices, the drive to look beyond what does exist to what can exist is ushering in an era of biology by design.
American Psychological Association (APA)
Fritz, Brian R.& Timmerman, Laura E.& Daringer, Nichole M.& Leonard, Joshua N.& Jewett, Michael C.. 2010. Biology by Design: From Top to Bottom and Back. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988816
Modern Language Association (MLA)
Fritz, Brian R.…[et al.]. Biology by Design: From Top to Bottom and Back. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-988816
American Medical Association (AMA)
Fritz, Brian R.& Timmerman, Laura E.& Daringer, Nichole M.& Leonard, Joshua N.& Jewett, Michael C.. Biology by Design: From Top to Bottom and Back. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988816