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A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer
Joint Authors
Schmieg, John
Tsuji, Moriya
Franck, Richard W.
Yang, Guangli
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We have previously shown that the C-glycoside analog of α-galactosylceramide (α-GalCer), α-C-GalCer, displays a superior inhibitory activity against the liver stages of the rodent malaria parasite Plasmodium yoelii than its parental glycolipid, α-GalCer.
In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by α-C-GalCer.
Surprisingly, the diminished production of Th2 cytokines, including IL-4, by α-C-GalCer has no affect on its superior therapeutic activity relative to α-GalCer.
Finally, we show that the in vivo administration of α-C-GalCer induces prolonged maturation of dendritic cells (DCs), as well as an enhanced proliferative response of mouse invariant Vα14 (Vα14i) NKT cells, both of which may also contribute to some degree to the superior activity of α-C-GalCer in vivo.
American Psychological Association (APA)
Schmieg, John& Yang, Guangli& Franck, Richard W.& Tsuji, Moriya. 2009. A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988839
Modern Language Association (MLA)
Schmieg, John…[et al.]. A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-988839
American Medical Association (AMA)
Schmieg, John& Yang, Guangli& Franck, Richard W.& Tsuji, Moriya. A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988839