Preparing sustained release alogliptin tablets using bentonite by granulation

Other Title(s)

تحضير مضغوطات مطولة التأثير لألوكليبتين باستخدام البنتونايت و بتقنية التحثير

Dissertant

Khalaf, al-Hamzah Hushi

Thesis advisor

al-Karad, Jamal al-Yusuf

University

Isra University

Faculty

Faculty of Pharmacy

University Country

Jordan

Degree

Master

Degree Date

2020

English Abstract

This study is designed to evaluate the use of bentonite to develop and optimize sustained release tablets by granulation method.

The tablets were prepared using different binders then tested for their pharmcopeal requirements.

Also, a HPLC method was developed to assess the release pattern of alogliptin from the tablets.

FTIR, DSC and powder-XRD were used to evaluate the compatibility between the drug and bentonite.

The results showed that the tablets comply with their compendial requirements and no interaction between the drug and the excipient.

Furthermore, the release profile revealed sustained release of aloglepitin from the tablets prepared with aid of hydroxypropyl methyl cellulose (HPMC) as a binder.

The data fitting showed that diffusion from the tablets followed Fickian model.

However, it could be possible to formulate successfully sustained release tablets of aloglpitin using bentonite as an excipient.

The formulated tablets complied with pharmacopeial requirements.

The developed tablets using bentonite by granulation are good candidate for further in vivo evaluation.

Main Topic

Pharmacology

Topics

No. of Pages

35

Table of Contents

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Methodology.

Chapter Three : Results.

Chapter Four : Discussion.

References.

American Psychological Association (APA)

Khalaf, al-Hamzah Hushi. (2020). Preparing sustained release alogliptin tablets using bentonite by granulation. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-988840

Modern Language Association (MLA)

Khalaf, al-Hamzah Hushi. Preparing sustained release alogliptin tablets using bentonite by granulation. (Master's theses Theses and Dissertations Master). Isra University. (2020).
https://search.emarefa.net/detail/BIM-988840

American Medical Association (AMA)

Khalaf, al-Hamzah Hushi. (2020). Preparing sustained release alogliptin tablets using bentonite by granulation. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-988840

Language

English

Data Type

Arab Theses

Record ID

BIM-988840