Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus
Joint Authors
Sarra, Massimiliano
Monteleone, Giovanni
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations.
Pathogenesis of SLE is complex and not fully understood.
There is however evidence that B and T cells are critical to the development of disease, and that T cell-derived cytokines are involved in the SLE-associated inflammatory response.
One such cytokine seems to be interleukin (IL)-21, the latest identified member of the γ-chain-related cytokine family.
IL-21 has an important role in the control of the growth, survival, differentiation, and function of both T and B cells, and excessive production of IL-21 has been associated with the development of multiple immune-mediated diseases.
Here we review data supporting the involvement of IL-21 in the pathogenesis of SLE.
American Psychological Association (APA)
Sarra, Massimiliano& Monteleone, Giovanni. 2010. Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus. BioMed Research International،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-988849
Modern Language Association (MLA)
Sarra, Massimiliano& Monteleone, Giovanni. Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus. BioMed Research International No. 2010 (Dec. 2010), pp.1-6.
https://search.emarefa.net/detail/BIM-988849
American Medical Association (AMA)
Sarra, Massimiliano& Monteleone, Giovanni. Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-988849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988849