![](/images/graphics-bg.png)
Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development
Joint Authors
Xiang, Zuoshuang
Mobley, Harry L. T.
He, Yongqun Oliver
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Vaxign is the first web-based vaccine design system that predicts vaccine targets based on genome sequences using the strategy of reverse vaccinology.
Predicted features in the Vaxign pipeline include protein subcellular location, transmembrane helices, adhesin probability, conservation to human and/or mouse proteins, sequence exclusion from genome(s) of nonpathogenic strain(s), and epitope binding to MHC class I and class II.
The precomputed Vaxign database contains prediction of vaccine targets for >70 genomes.
Vaxign also performs dynamic vaccine target prediction based on input sequences.
To demonstrate the utility of this program, the vaccine candidates against uropathogenic Escherichia coli (UPEC) were predicted using Vaxign and compared with various experimental studies.
Our results indicate that Vaxign is an accurate and efficient vaccine design program.
American Psychological Association (APA)
He, Yongqun Oliver& Xiang, Zuoshuang& Mobley, Harry L. T.. 2010. Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development. BioMed Research International،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-988850
Modern Language Association (MLA)
He, Yongqun Oliver…[et al.]. Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development. BioMed Research International No. 2010 (Dec. 2010), pp.1-15.
https://search.emarefa.net/detail/BIM-988850
American Medical Association (AMA)
He, Yongqun Oliver& Xiang, Zuoshuang& Mobley, Harry L. T.. Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-988850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988850