Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota
Joint Authors
Neu, Josef
Young, Christopher
Sharma, Renu
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The daunting task required of the gut-barrier to prevent luminal pathogens and harmful substances from entering into the internal milieu and yet promoting digestion and absorption of nutrients requires an exquisite degree of coordination between the different architectural units of this barrier.
The complex integration and execution of these functions are superbly carried out by the intestinal mucosal (IM) surface.
Exposed to trillions of luminal microbes, the IM averts threats by signaling to the innate immune system, through pattern recognition receptors (PRR), to respond to the commensal bacteria by developing tolerance (hyporesponsiveness) towards them.
This system also acts by protecting against pathogens by elaborating and releasing protective peptides, cytokines, chemokines, and phagocytic cells.
The IM is constantly sampling luminal contents and making molecular adjustments at its frontier.
This article describes the topography of the IM and the mechanisms of molecular adjustments that protect the internal milieu, and also describes the role of the microbiota in achieving this goal.
American Psychological Association (APA)
Sharma, Renu& Young, Christopher& Neu, Josef. 2009. Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota. BioMed Research International،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-988853
Modern Language Association (MLA)
Sharma, Renu…[et al.]. Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota. BioMed Research International No. 2010 (Dec. 2010), pp.1-15.
https://search.emarefa.net/detail/BIM-988853
American Medical Association (AMA)
Sharma, Renu& Young, Christopher& Neu, Josef. Molecular Modulation of Intestinal Epithelial Barrier: Contribution of Microbiota. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-988853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988853