Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188
Joint Authors
Mudrov, Nikola
Tsoneva, Iana
Berger, Annette J.
Nikolova, Biliana
Tomov, Toma
Berger, Martin R.
Iordanov, Iordan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules (cisplatin, bleomycin, or propidium iodide) can pass/diffuse.
It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures.
The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability.
Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase.
The volume of tumors stopped to grow after electrochemotherapy and the use of poloxamer 188 reduced the edema near the electrode and around the subcutaneously growing tumors.
American Psychological Association (APA)
Tsoneva, Iana& Iordanov, Iordan& Berger, Annette J.& Tomov, Toma& Nikolova, Biliana& Mudrov, Nikola…[et al.]. 2010. Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988856
Modern Language Association (MLA)
Tsoneva, Iana…[et al.]. Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-988856
American Medical Association (AMA)
Tsoneva, Iana& Iordanov, Iordan& Berger, Annette J.& Tomov, Toma& Nikolova, Biliana& Mudrov, Nikola…[et al.]. Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988856