Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3: A Novel Antimicrobial Agent
Joint Authors
Zhang, Guozhong
Hu, Yanxin
Sun, Lun-Quan
Cao, Shanping
Sun, Juan
Wang, Ming
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nu-3 [butyl-phosphate-5′-thymidine-3′-phosphate-butyl] is a modified nucleotide that has been shown to have antimicrobial activity against a range of bacteria including Pseudomonas aeruginosa.
However, data on the toxicological profile of Nu-3 are still lacking.
In the present study, the toxicity of Nu-3 was evaluated by the following studies: acute oral toxicity, dermal and mucous membrane irritation, multiple-dose toxicity and genotoxicity in vivo and vitro.
The acute oral toxicity test in mice showed that Nu-3 had an LD50 of 2001mg/kg body weight.
The irritation tests on rats revealed that Nu-3 was not irritant, with an irritation scoring of 0.
The multiple-dose toxicity study in rats showed that Nu-3 did not cause significant changes in histology, selected serum chemistry, and hematological parameters compared to the controls.
Rats administrated with multiple-doses of Nu-3 showed no visible toxic symptoms.
Both in vitro and in vivo, Nu-3 exhibited no notable genetic toxicity.
Overall, the data suggest that Nu-3 is hypotoxic or nontoxic antimicrobial compound that warrants being further developed for treating Pseudomonas aeruginosa infection.
American Psychological Association (APA)
Sun, Juan& Hu, Yanxin& Cao, Shanping& Zhang, Guozhong& Sun, Lun-Quan& Wang, Ming. 2010. Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3: A Novel Antimicrobial Agent. BioMed Research International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-988877
Modern Language Association (MLA)
Sun, Juan…[et al.]. Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3: A Novel Antimicrobial Agent. BioMed Research International No. 2010 (Dec. 2010), pp.1-8.
https://search.emarefa.net/detail/BIM-988877
American Medical Association (AMA)
Sun, Juan& Hu, Yanxin& Cao, Shanping& Zhang, Guozhong& Sun, Lun-Quan& Wang, Ming. Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3: A Novel Antimicrobial Agent. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-988877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988877