Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression
Joint Authors
Cui, Wei
Muddasani, Ramya
Lu, Gary
Bueso-Ramos, Carlos E.
Sun, Jianlan
Chen, Su S.
Yin, C. Cameron
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Trisomy 14 is a rare recurrent cytogenetic abnormality in myeloid neoplasms; however, its clinicopathologic features have not been well described.
We report the clinicopathologic, immunophenotypic, and molecular genetic features of 16 cases of myeloid neoplasms with isolated trisomy 14.
Our results show that cases with isolated trisomy 14 encompass a heterogenous group of myeloid neoplasms including myelodysplastic syndrome (MDS, 44%), myelodysplastic/myeloproliferative neoplasms (31%), and acute myeloid leukemia (25%).
The patients are usually elder (median age 71 years), and there is a male predominance (82%).
Multilineage dysplasia is noted in all cases.
Oncogenic mutations of genes involved in cell proliferation and/or survival rarely occur.
Compared with cases of MDS with diploid karyotype, patients of MDS with isolated trisomy 14 demonstrate a similar overall survival and rate of leukemia transformation.
American Psychological Association (APA)
Cui, Wei& Bueso-Ramos, Carlos E.& Yin, C. Cameron& Sun, Jianlan& Chen, Su S.& Muddasani, Ramya…[et al.]. 2010. Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988879
Modern Language Association (MLA)
Cui, Wei…[et al.]. Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-988879
American Medical Association (AMA)
Cui, Wei& Bueso-Ramos, Carlos E.& Yin, C. Cameron& Sun, Jianlan& Chen, Su S.& Muddasani, Ramya…[et al.]. Trisomy 14 as a Sole Chromosome Abnormality Is Associated with Older Age, a Heterogenous Group of Myeloid Neoplasms with Dysplasia, and a Wide Spectrum of Disease Progression. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988879
