Infection with Hymenolepis diminuta Is More Effective than Daily Corticosteroids in Blocking Chemically Induced Colitis in Mice
Joint Authors
Phan, Van
McKay, Derek M.
Melon, Alexandra
Wang, Arthur
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To compare infection with the tapeworm, Hymenolepis diminuta, with steroid (dexamethasone) administration in the inhibition of dinitrobenzene sulfonic acid- (DNBS-) induced colitis in mice.
Procedures.
Mice were treated with DNBS ± infected with H.
diminuta or treated with daily dexamethasone (2 mg/Kg, ip.) and were assessed 72 hours post-DNBS by the calculation of disease activity and histological damage scores, and spleen cell cytokine production.
Results.
H.
diminuta-infected mice showed increased IL-4 and IL-10 production by spleen cells compared to other groups and were protected from DNBS-induced colitis.
In contrast, there was little benefit of dexamethasone in the treatment of colitis.
Collagen deposition in the colon was not different between the groups.
Conclusions.
H.
diminuta was superior to dexamethasone in the prevention of DNBS-induced colitis and did not result in additional side effects (i.e., collagen deposition).
Comparisons with current therapeutics and long-term followup to studies are essential if “helminth therapy” is to become a viable treatment for specific inflammatory diseases in the gut or other tissues.
American Psychological Association (APA)
Melon, Alexandra& Wang, Arthur& Phan, Van& McKay, Derek M.. 2009. Infection with Hymenolepis diminuta Is More Effective than Daily Corticosteroids in Blocking Chemically Induced Colitis in Mice. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988887
Modern Language Association (MLA)
Melon, Alexandra…[et al.]. Infection with Hymenolepis diminuta Is More Effective than Daily Corticosteroids in Blocking Chemically Induced Colitis in Mice. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-988887
American Medical Association (AMA)
Melon, Alexandra& Wang, Arthur& Phan, Van& McKay, Derek M.. Infection with Hymenolepis diminuta Is More Effective than Daily Corticosteroids in Blocking Chemically Induced Colitis in Mice. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988887