Analysis of Adiponectin Gene Polymorphisms in Chinese Population with Systemic Lupus Erythematosus
Joint Authors
Zhou, Bin
Chen, Yu
Zhang, Lin
Fang, Wen Liang
Wang, Yan Yun
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease.
Adiponectin is an adipocyte-derived cytokine with anti-inflammatory, antidiabetic, and antiatherogenic properties.
No study has reported on the association between adiponectin (ADIPOQ) gene and SLE.
Our aim is to investigate the association between single-nucleotide polymorphisms in ADIPOQ gene and SLE.
We examined 179 SLE patients and 237 age- and gender-matched controls from Sichuan province in China.
Genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing.
Results show that there was no significant difference in the allele frequencies of rs1501299 (P=.311, OR=1.17, 95% CI: 0.86–1.59) and rs2241766 (P=.929, OR=0.99, 95% CI: 0.74–1.33) in ADIPOQ gene between SLE patients and controls.
The same results were seen in their genotypes (P<.05).
The allele frequencies of rs1501299 and rs2241766 polymorphisms of ADIPOQ may not be associated with SLE risk.
American Psychological Association (APA)
Fang, Wen Liang& Zhou, Bin& Wang, Yan Yun& Chen, Yu& Zhang, Lin. 2010. Analysis of Adiponectin Gene Polymorphisms in Chinese Population with Systemic Lupus Erythematosus. BioMed Research International،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-988896
Modern Language Association (MLA)
Fang, Wen Liang…[et al.]. Analysis of Adiponectin Gene Polymorphisms in Chinese Population with Systemic Lupus Erythematosus. BioMed Research International No. 2010 (Dec. 2010), pp.1-5.
https://search.emarefa.net/detail/BIM-988896
American Medical Association (AMA)
Fang, Wen Liang& Zhou, Bin& Wang, Yan Yun& Chen, Yu& Zhang, Lin. Analysis of Adiponectin Gene Polymorphisms in Chinese Population with Systemic Lupus Erythematosus. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-988896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988896