Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium
Joint Authors
Sato, Hiroyoshi
Saito, Akihiko
Takeda, Tetsuro
Iino, Noriaki
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Receptor-mediated endocytosis is a pivotal function of renal proximal tubule epithelial cells (PTECs) to reabsorb and metabolize substantial amounts of proteins and other substances in glomerular filtrates.
The function accounts for the conservation of nutrients, including carrier-bound vitamins and trace elements, filtered by glomeruli.
Impairment of the process results in a loss of such substances and development of proteinuria, an important clinical sign of kidney disease and a risk marker for cardiovascular disease.
Megalin is a multiligand endocytic receptor expressed at clathrin-coated pits of PTEC, playing a central role in the process.
Megalin cooperates with various membrane molecules and interacts with many intracellular adaptor proteins for endocytic trafficking.
Megalin is also involved in signaling pathways in the cells.
Megalin-mediated endocytic overload leads to damage of PTEC.
Further studies are needed to elucidate the mechanism of megalin-mediated endocytosis and develop strategies for preventing the damage of PTEC.
American Psychological Association (APA)
Saito, Akihiko& Sato, Hiroyoshi& Iino, Noriaki& Takeda, Tetsuro. 2009. Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988899
Modern Language Association (MLA)
Saito, Akihiko…[et al.]. Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-988899
American Medical Association (AMA)
Saito, Akihiko& Sato, Hiroyoshi& Iino, Noriaki& Takeda, Tetsuro. Molecular Mechanisms of Receptor-Mediated Endocytosis in the Renal Proximal Tubular Epithelium. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988899