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Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44
Joint Authors
Longatto-Filho, Adhemar
Schmitt, Fernando
Pinheiro, Céline
Baltazar, Fátima
Ricardo, Sara
Reis, Rui M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Monocarboxylate transporters (MCTs) are important cellular pH regulators in cancer cells; however, the value of MCT expression in cancer is still poorly understood.
In the present study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as CD147 and CD44.
MCT expression frequency was high and heterogeneous among the different tumours.
Comparing with normal tissues, there was an increase in MCT1 and MCT4 expressions in breast carcinoma and a decrease in MCT4 plasma membrane expression in lung cancer.
There were associations between CD147 and MCT1 expressions in ovarian cancer as well as between CD147 and MCT4 in both breast and lung cancers.
CD44 was only associated with MCT1 plasma membrane expression in lung cancer.
An important number of MCT1 positive cases are negative for both chaperones, suggesting that MCT plasma membrane expression in tumours may depend on a yet nonidentified regulatory protein.
American Psychological Association (APA)
Pinheiro, Céline& Reis, Rui M.& Ricardo, Sara& Longatto-Filho, Adhemar& Schmitt, Fernando& Baltazar, Fátima. 2010. Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988911
Modern Language Association (MLA)
Pinheiro, Céline…[et al.]. Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-988911
American Medical Association (AMA)
Pinheiro, Céline& Reis, Rui M.& Ricardo, Sara& Longatto-Filho, Adhemar& Schmitt, Fernando& Baltazar, Fátima. Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988911