Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?
Joint Authors
McSherry, Elaine A.
Offiah, Gozie
Brennan, Kieran
Hopkins, Ann M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Breast cancer is a complex and heterogeneous disease that arises from epithelial cells lining the breast ducts and lobules.
Correct adhesion between adjacent epithelial cells is important in determining the normal structure and function of epithelial tissues, and there is accumulating evidence that dysregulated cell-cell adhesion is associated with many cancers.
This review will focus on one cell-cell adhesion complex, the tight junction (TJ), and summarize recent evidence that TJs may participate in breast cancer development or progression.
We will first outline the protein composition of TJs and discuss the functions of the TJ complex.
Secondly we will examine how alterations in these functions might facilitate breast cancer initiation or progression; by focussing on the regulatory influence of TJs on cell polarity, cell fate and cell migration.
Finally we will outline how pharmacological targeting of TJ proteins may be useful in limiting breast cancer progression.
Overall we hope to illustrate that the relationship between TJ alterations and breast cancer is a complex one; but that this area offers promise in uncovering fundamental mechanisms linked to breast cancer progression.
American Psychological Association (APA)
Brennan, Kieran& Offiah, Gozie& McSherry, Elaine A.& Hopkins, Ann M.. 2009. Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?. BioMed Research International،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-988925
Modern Language Association (MLA)
Brennan, Kieran…[et al.]. Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?. BioMed Research International No. 2010 (Dec. 2010), pp.1-16.
https://search.emarefa.net/detail/BIM-988925
American Medical Association (AMA)
Brennan, Kieran& Offiah, Gozie& McSherry, Elaine A.& Hopkins, Ann M.. Tight Junctions: A Barrier to the Initiation and Progression of Breast Cancer?. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-988925
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988925