Pathogenesis of Insulin Resistance in Skeletal Muscle
Joint Authors
Abdul-Ghani, Muhammad A.
DeFronzo, Ralph A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-15
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Insulin resistance in skeletal muscle is manifested by decreased insulin-stimulated glucose uptake and results from impaired insulin signaling and multiple post-receptor intracellular defects including impaired glucose transport, glucose phosphorylation, and reduced glucose oxidation and glycogen synthesis.
Insulin resistance is a core defect in type 2 diabetes, it is also associated with obesity and the metabolic syndrome.
Dysregulation of fatty acid metabolism plays a pivotal role in the pathogenesis of insulin resistance in skeletal muscle.
Recent studies have reported a mitochondrial defect in oxidative phosphorylation in skeletal muscle in variety of insulin resistant states.
In this review, we summarize the cellular and molecular defects that contribute to the development of insulin resistance in skeletal muscle.
American Psychological Association (APA)
Abdul-Ghani, Muhammad A.& DeFronzo, Ralph A.. 2010. Pathogenesis of Insulin Resistance in Skeletal Muscle. BioMed Research International،Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-988931
Modern Language Association (MLA)
Abdul-Ghani, Muhammad A.& DeFronzo, Ralph A.. Pathogenesis of Insulin Resistance in Skeletal Muscle. BioMed Research International No. 2010 (Dec. 2010), pp.1-19.
https://search.emarefa.net/detail/BIM-988931
American Medical Association (AMA)
Abdul-Ghani, Muhammad A.& DeFronzo, Ralph A.. Pathogenesis of Insulin Resistance in Skeletal Muscle. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-988931
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988931