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Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality
Joint Authors
Cheng, Ruei-Tang
Chen, Sheng-Hsien
Lin, Mao- Tsun
Lin, Chian-Yuh
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
When the vehicle-treated, sham-operated mice underwent heat stress, the fraction survival and core temperature at +4 h of body heating were found to be 5 of 15 and 34.4∘C±0.3∘C, respectively.
Castration 2 weeks before the start of heat stress decreased the plasma levels of testosterone almost to zero, protected the mice from heat-induced death (fraction survival, 13/15) and reduced the hypothermia (core temperature, 37.3∘C).
The beneficial effects of castration in ameliorating lethality and hypothermia can be significantly reduced by testosterone replacement.
Heat-induced apoptosis, as indicated by terminal deoxynucleotidyl- transferase- mediatedαUDP-biotin nick end-labeling staining, were significantly prevented by castration.
In addition, heat-induced neuronal damage, as indicated by cell shrinkage and pyknosis of nucleus, to the hypothalamus was also castration-prevented.
Again, the beneficial effects of castration in reducing neuronal damage to the hypothalamus as well as apoptosis in multiple organs during heatstroke, were significantly reversed by testosterone replacement.
The data indicate that testosterone depletion by castration may protect mice from heatstroke-induced multiple organ damage and lethality.
American Psychological Association (APA)
Lin, Chian-Yuh& Lin, Mao- Tsun& Cheng, Ruei-Tang& Chen, Sheng-Hsien. 2010. Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality. BioMed Research International،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-988937
Modern Language Association (MLA)
Lin, Chian-Yuh…[et al.]. Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality. BioMed Research International No. 2010 (Dec. 2010), pp.1-9.
https://search.emarefa.net/detail/BIM-988937
American Medical Association (AMA)
Lin, Chian-Yuh& Lin, Mao- Tsun& Cheng, Ruei-Tang& Chen, Sheng-Hsien. Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-988937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988937