Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68
Joint Authors
Heisig, Martin
Weibel, Stephanie
Gentschev, Ivaylo
Donat, Ulrike
Raab, Viktoria
Chen, Nanhai G.
Adelfinger, Marion
Yu, Yong A.
Szalay, Aladar A.
Hofmann, Elisabeth
Stritzker, Jochen
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Virotherapy using oncolytic vaccinia virus strains is one of the most promising new strategies for cancer therapy.
In the current study, we analyzed the therapeutic efficacy of the oncolytic vaccinia virus GLV-1h68 against two human prostate cancer cell lines DU-145 and PC-3 in cell culture and in tumor xenograft models.
By viral proliferation assays and cell survival tests, we demonstrated that GLV-1h68 was able to infect, replicate in, and lyse these prostate cancer cells in culture.
In DU-145 and PC-3 tumor xenograft models, a single intravenous injection with GLV-1h68 resulted in a significant reduction of primary tumor size.
In addition, the GLV-1h68-infection led to strong inflammatory and oncolytic effects resulting in drastic reduction of regional lymph nodes with PC-3 metastases.
Our data documented that the GLV-1h68 virus has a great potential for treatment of human prostate carcinoma.
American Psychological Association (APA)
Gentschev, Ivaylo& Donat, Ulrike& Hofmann, Elisabeth& Weibel, Stephanie& Adelfinger, Marion& Raab, Viktoria…[et al.]. 2010. Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68. BioMed Research International،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988940
Modern Language Association (MLA)
Gentschev, Ivaylo…[et al.]. Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68. BioMed Research International No. 2010 (Dec. 2010), pp.1-11.
https://search.emarefa.net/detail/BIM-988940
American Medical Association (AMA)
Gentschev, Ivaylo& Donat, Ulrike& Hofmann, Elisabeth& Weibel, Stephanie& Adelfinger, Marion& Raab, Viktoria…[et al.]. Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-988940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988940
