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The Unexpected Role for the Aryl Hydrocarbon Receptor on Susceptibility to Experimental Toxoplasmosis
Joint Authors
Sanchez, Yuriko
Estrada-Muñiz, Elizabeth
de Dios Rosado, Juan
Juárez, Imelda
Elizondo, Guillermo
Vega, Libia
Saavedra, Rafael
Rodríguez-Sosa, Miriam
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-06
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The aryl hydrocarbon receptor (AhR) is part of a signaling system that is mainly triggered by xenobiotic agents.
Increasing evidence suggests that AhR may regulate immunity to infections.
To determine the role of AhR in the outcome of toxoplasmosis, we used AhR-/- and wild-type (WT) mice.
Following an intraperitoneal infection with Toxoplasma gondii (T.
gondii), AhR-/- mice succumbed significantly faster than WT mice and displayed greater liver damage as well as higher serum levels of tumor necrosis factor (TNF)-α, nitric oxide (NO), and IgE but lower IL-10 secretion.
Interestingly, lower numbers of cysts were found in their brains.
Increased mortality was associated with reduced expression of GATA-3, IL-10, and 5-LOX mRNA in spleen cells but higher expression of IFN-γ mRNA.
Additionally, peritoneal exudate cells from AhR-/- mice produced higher levels of IL-12 and IFN-γ but lower TLR2 expression than WT mice.
These findings suggest a role for AhR in limiting the inflammatory response during toxoplasmosis.
American Psychological Association (APA)
Sanchez, Yuriko& de Dios Rosado, Juan& Vega, Libia& Elizondo, Guillermo& Estrada-Muñiz, Elizabeth& Saavedra, Rafael…[et al.]. 2009. The Unexpected Role for the Aryl Hydrocarbon Receptor on Susceptibility to Experimental Toxoplasmosis. BioMed Research International،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-988945
Modern Language Association (MLA)
Sanchez, Yuriko…[et al.]. The Unexpected Role for the Aryl Hydrocarbon Receptor on Susceptibility to Experimental Toxoplasmosis. BioMed Research International No. 2010 (Dec. 2010), pp.1-15.
https://search.emarefa.net/detail/BIM-988945
American Medical Association (AMA)
Sanchez, Yuriko& de Dios Rosado, Juan& Vega, Libia& Elizondo, Guillermo& Estrada-Muñiz, Elizabeth& Saavedra, Rafael…[et al.]. The Unexpected Role for the Aryl Hydrocarbon Receptor on Susceptibility to Experimental Toxoplasmosis. BioMed Research International. 2009. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-988945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988945