Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus
Joint Authors
Abe, Tohru
Yoshimoto, Keiko
Takeuchi, Tsutomu
Tsuzaka, Kensei
Setoyama, Yumiko
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2009), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Accumulating evidence suggests that dysfunction of T cells underlies the pathogenesis of systemic lupus erythematosus (SLE).
We revealed that SLE T cells produced an abnormally excessive amount of IFN-γin vitro upon stimulation through TCR, and the expression level of TCR zeta was significantly reduced.
The production of IFN-γ by SLE T cells was negatively correlated with the expression level of TCR zeta.
This correlation was abolished when the cells were stimulated with TPA and ionomycin, which bypass TCR and introduce signals directly into the cells, but the production of IFN-γ by SLE T cells remained abnormally elevated.
Taken together, these data suggest that regulatory mechanisms not only for the expression of TCR zeta but also for the production of IFN-γ were impaired in SLE T cells.
These impairments may be responsible for the aberrant responses of SLE T cells and partly involved in the development of SLE.
American Psychological Association (APA)
Yoshimoto, Keiko& Setoyama, Yumiko& Tsuzaka, Kensei& Abe, Tohru& Takeuchi, Tsutomu. 2010. Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus. BioMed Research International،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-988949
Modern Language Association (MLA)
Yoshimoto, Keiko…[et al.]. Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus. BioMed Research International No. 2010 (Dec. 2010), pp.1-6.
https://search.emarefa.net/detail/BIM-988949
American Medical Association (AMA)
Yoshimoto, Keiko& Setoyama, Yumiko& Tsuzaka, Kensei& Abe, Tohru& Takeuchi, Tsutomu. Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-988949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-988949